Whole genome sequencing and genotyping Klebsiella pneumoniae multi-drug resistant hospital isolates from Western Kenya

This study aimed to sequence 15 Klebsiella pneumoniae isolates from a referral hospital in Kakamega, Kenya, for genotyping and identification of antimicrobial resistance (AMR) and virulence determinants. The results showed that ST147 was the dominant lineage among highly-resistant isolates, associated with both community- and hospital-acquired infections. Multiple antibiotic resistance and virulence determinants were detected, including extended-spectrum β-lactamases and carbapenemases, many of which were plasmid-borne. The findings suggest an influx of new nosocomial pathogens with new virulence genes into African hospitals.